Metformin weight loss antipsychotics
The Use of Metformin in the Treatment of Antipsychotic-Induced Weight Gain in Schizophrenia (The METS Study) (METS). Metformin has also been shown to cause weight loss in preliminary studies of people taking atypical antipsychotics—a newer, second generation of antipsychotic medications. 0 kg on average, while weight was stable in the metformin group. In the four month study done in the US, Dr. A service of the U. We have not reviewed the actual journal articles - so we recommend you have your doctor assess the viability of this avenue as a possible means to prevent weight gain. Klein et al. Unfortunately, a side effect of many antipsychotics is unwanted weight gain, which can lead to physical illness. Over 4 months, the patients taking placebo gained an additional 4. Since the substantial weight gain produced by second-generation antipsychotics can decrease compliance with treatment, metformin also has the potential to increase compliance and improve outcome. Schizophrenia is a chronic mental disorder that is characterized, in part, by psychotic symptoms. 2072) compared metformin and placebo in 39 children and adolescents ages 10-17 who had gained at least 10% of their pretreatment weight while taking olanzapine, risperidone, or quetiapine. Further study details as provided by National Institute of Mental Health (NIMH). Antipsychotic drugs are a standard and important treatment for people who have schizophrenia - but the side effects of weight gain and diabetes are something that a significant portion of people also suffer from. Metformin is currently approved by the Food and Drug Administration to treat only people with diabetes. We recommend you print out this information and take it to your doctor, if you (or someone you know) are taking anti-psychotic medications. February 2010 (Final data collection date for primary outcome measure). Metformin is used by millions of diabetics each day in the US - so its a well established and effective drug. National Institutes of Health. However, the metformin group had a decrease in weight relative to height, as measured by body mass index, because the study was conducted in growing children.
Participation in this study will last 16 weeks. The study will also provide important feasibility information for future larger studies. Kenneth Towbin discusses the importance of this study in an editorial here: Gaining: Pediatric Patients and Use of Atypical Antipsychotics. This study will test the usefulness of the medication metformin in treating people with schizophrenia or schizoaffective disorder who are overweight and also taking antipsychotic medications. S. Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor) Primary Purpose: Treatment. But those who also took Metformin lost a little weight. This study will test the usefulness of prescribing metformin as a second medication to treat people with schizophrenia or schizoaffective disorder who are overweight and taking antipsychotics. The study was published in the American Journal of Psychiatry. The mean changes in weight and body mass index at 12 weeks were highly significant. Metformin in the Treatment of Antipsychotic-Induced Weight Gain in Schizophrenia (METS) - Pilot Study. Use of the drug metformin has resulted in weight loss among diabetics. Psychotic symptoms include hallucinations and delusions, in which a person has abnormal experiences or beliefs, and are commonly treated with antipsychotic medications. Metformin halted weight gain and decreased measures of insulin resistance. (p. Dr. Gaining: Pediatric Patients and Use of Atypical Antipsychotics. NOTE: There are two other recent studies focusing on Metformin use for weight prevention in young people using anti-psychotic medications. Daily Schizophrenia-related news, commentary and links to additional information. Klein found that kids on antipsychotic medications gained an average of nearly nine pounds.
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